Microbial diversity and pharmaceutical biotransformations
Collaborators: Lauren B. Stadler
Stadler, L.B.†, Delgado Vela, J. †, Jain, S., Dick, G., and Love, N. G. Elucidating the Relationship between Wastewater Treatment Plant Microbial Diversity and Pharmaceutical Fate. 2017. Microbial Biotechnology. DOI: 10.1111/1751-7915.12870
- Do functional and taxonomic diversity associate with each other in wastewater treatment plant microbial communities?
- How does wastewater treatment plant microbial diversity impact pharmaceutical biotransformations?
- Which functions associate with pharmaceutical biotransformations?
Established diversity gradient using wastewater microbial community
Regrew diluted cultures and performed pharamceutical biotransformation assays.
Analyzed sequencing data, amplicon sequencing of the 16S rRNA gene and 16S rRNA, as well as whole community metagenomics and metatranscriptomics, to identify the functions and taxonomic groups that were lost in the dilution gradient.